Franco-Italian War (1542–1546)

Timeline

1. 1542Border of the Duchy of Milan · LombardyIn 1542 Francis I and Charles V's alliance went to war again; French forces advanced into northern Italy, targeting Milan and Savoy, while coordinating an offensive against Perpignan in Roussillon to tie down imperial border defenses.
2. 1544Crépy-en-Valois · PicardyOn September 18, 1544, France and Spain signed a peace treaty at Crépy: Francis I renounced his claims to Flanders, while Charles V renounced his claims to Burgundy; the treaty temporarily halted full-scale war but did not resolve the fundamental conflict over Italy.
3. 1546Italian Peninsula · ItalyIn 1546 the peace treaty failed to last; French forces were again checked in Italy, and the Holy Roman Empire and Spain consolidated their control over Milan, creating conditions for the continuation of subsequent cycles of war.