Eurasian Plague Epidemic of the 1480s

Timeline

1. c. 1483–1485Northern Italy · LombardyAround 1483, cities in northern Italy reported a surge in plague cases; Milan and others adopted quarantine and sanitary regulations, restricting commercial activity and social gatherings, becoming one of the important starting points of this European wave.
2. c. 1484–1486Germany and the Netherlands · Holy Roman EmpireThe epidemic spread north along the Rhine and Hanseatic trade routes, with deaths reported successively in German cities and the Low Countries; local authorities implemented port quarantines, market restrictions, and patient isolation to curb its spread.
3. c. 1485–1488Eurasian trade routes · EurasiaIn the later 1480s, port cities in Western Europe such as England were still affected by the aftermath; at the same time, plague was also recorded on the borders of eastern empires and along Central Asian trade routes, demonstrating the key role of Eurasian trade networks in the cross-regional spread of plague.