Mixtón War

Name: Mixtón War
Start: 1541
End: 1542

Type Event Region New Spain Time 1541–1542

From 1541 to 1542, a large-scale indigenous uprising erupted in western New Spain (modern Jalisco, Zacatecas, etc.), known as the Mixtón War.

Timeline

1541Tepeaca · New SpainLocal indigenous people, long embittered by tribute, forced labor, and religious oppression, rose simultaneously at Tepeaca, Mixtón, and other places, attacking Spanish settlements and killing several colonists.
1541–1542Mixtón · New SpainViceroy Mendoza dispatched Alvarado and others to besiege the mountain fortresses of the rebel strongholds, using artillery and cavalry assaults and carrying out mass executions of resisters; by early 1542 the uprising was completely crushed.

Mixtón War https://www.britannica.com/event/Mixton-War
The Mixton War of 1541-42 and Its Impact on the Chichimeca Frontier — Philip Wayne Powell (1952)